We all know that most people with mental illness are intractable, with some being repeatedly hospitalized more than a dozen times or even dozens of times, and with long hospital stays of up to six months or several years. Many people do not believe that there is a cure for mental illness that can produce immediate results. But the fact is that there are treatments that work in a short period of time, even as soon as the treatment is completed. This method is neuromodulation, which includes modern minimally invasive psychosurgery, and the results can be seen as soon as the procedure is completed, so it is said to be immediate. Why is the effect so miraculous? According to modern neurobiology and neuroimaging research, it is found that psychiatric disorders are due to abnormal functions of neurotransmitters in different brain regions and their neural networks and neural loops. Psychiatric disorders involve brain regions such as the prefrontal lobe, the anterior limb of the internal capsule, and the limbic system, such as the anterior cingulate gyrus, the nucleus ambiguus, and the amygdala-hippocampal complex. The networks involved such as the executive network, default network, and emergent network are abnormal. The neurotransmitters are mainly abnormalities of dopaminergic and 5-hydroxytryptaminergic. The reason why drug therapy is slow to work or ineffective is that drugs have to go through a series of biological metabolism, decomposition, transport and binding to relevant neuroreceptors after entering the brain, and also through the regulation of biological messengers, gene expression, etc. before they can exert their biological effects. For various reasons, the affinity between the drug and the receptor is poor, or the long-term receptor “neurotoxic excitation” has damaged the nerve cell structure, resulting in organic damage to the neural tissue (this is why the longer the course of mental illness, the worse the efficacy, and finally become intractable diseases), which can make the drug completely ineffective. Due to the above reasons, medication for psychiatric treatment is slow to start and ineffective. Surgical treatment, on the other hand, directly regulates the above-mentioned lesions and blocks their psychopathic impulses directly, so that the effect can be seen immediately after waking up from surgical anesthesia, for example, the mood is immediately stabilized, those who are grumpy immediately become mild and take the initiative to talk, the affection for loved ones is immediately restored, those who are depressed and want to die disappear after surgery, those who refuse to eat take the initiative to eat; those who are addicted to drugs “heart addiction” or “alcohol addiction The “heart addiction” or “alcohol addiction” of drug addicts disappears immediately, and the “heart” of drug addicts is no longer seen, etc. What are the advantages compared to drug treatment? The advantages of minimally invasive surgery versus drug treatment are that the results are quick and immediate; secondly, most of the symptoms disappear more completely than drug treatment; thirdly, both negative and positive symptoms are effective; fourthly, some patients can still achieve good results despite the long duration of the disease; fifthly, surgery can improve the sensitivity and effectiveness of drugs and generally reduce the number of drugs taken after surgery; sixthly, because of the reduction of drugs, the adverse effects of drugs are greatly reduced or avoided. adverse reactions, such as reducing the toxic effects of drugs on the heart, liver, kidneys and blood, and the adverse effects on metabolism, which is conducive to preventing diabetes or alleviating it. The disadvantage is obviously the higher cost, although most patients may be low if they count from the long-term hospitalization cost, because the medical cost should be reduced instead without recurrence or less recurrence after surgery; secondly, it is invasive, although this trauma is very small and basically has little effect on the body; thirdly, there are still minor adverse effects, such as fumbling movements, urinary incontinence within 2-5 days, short-term near memory loss, etc., which basically disappear within 2 weeks or recovery. What are the types of neuromodulation techniques? They are generally classified into electrical stimulation, which is divided into deep and cortical electrical stimulation, such as deep brain stimulation (DBSA) for the former and artificial hippocampal implantation for Alzheimer’s disease and vagus nerve stimulation for the latter; minimally invasive ablation, including thermocoagulation and radiation irradiation; miniature drug pumps or capsules buried under the scalp and catheters implanted into specific parts of the brain for continuous administration of drugs, such as continuous administration of analgesics for malignant pain, continuous administration of antispasmodics for post-stroke limb Continuous administration of antispasmodics for movement disorders, continuous administration of neurotrophic factors for Alzheimer’s and Parkinson’s disease, etc. Which patients are suitable for neuromodulation minimally invasive surgery treatment? It is mainly suitable for refractory psychiatric diseases that are not effective with drug treatment or are effective but easily relapsed, such as schizophrenia, bipolar disorder, depression, mania, paranoid psychosis, obsessive-compulsive disorder, anxiety disorder, phobia, personality disorder, autistic behavior disorder, drug dependence including alcohol addiction, epilepsy and epilepsy-induced mental disorders, Parkinson’s disease, etc.; aged between 18 and 60 years; with standardized medication; more than 5 years of disease duration; the main indication for deep brain electrical stimulation is Parkinson’s disease. Contraindications, such as young age, short duration of disease, involuntary patients, unknown diagnosis, unreasonable expectations of treatment by family members, and physical conditions that cannot withstand anesthesia or surgery.