Patients with kidney stones can have elevated protein in the urine, which can be divided into two cases: 1, urinary system infection caused by prolonged stimulation of kidney stones, prolonged urinary system infection to form chronic inflammation, resulting in chronic pyelonephritis and interstitial fibrosis in the kidney, which will eventually affect the filtration function of the glomerulus, thus affecting the physiological changes in the filtration membrane of the glomerulus, which will lead to protein This can lead to leakage of protein into the urine. This is a complication of kidney stones, secondary to proteinuria.2. Due to the irritation of the mucosa of the urinary epithelium during the discharge of kidney stones, local inflammatory manifestations such as congestion and edema may occur. If further aggravated, it will lead to inflammatory processes such as protein exudation or leakage from the surrounding tissues, and elevated protein will be detected in the urine. In this case, after the stone is discharged, with normal anti-inflammatory and symptomatic treatment and recovery, the protein will return to normal and disappear when the urine routine is rechecked. If the kidney stone is secondary to glomerulonephritis, the patient needs to have 24-hour protein urine quantification in time to clarify whether there are complications of the stone.