Cholinergic urticaria, also known as heat urticaria, is mainly caused by heat, nervousness or intake of hot drinks, or an increase in body temperature and blood flow after a serious illness, while the temperature of the blood flow increases, which can stimulate the thermoregulatory center of the brain, excite the cholinergic nerves and release acetylcholine. If the body is allergic to acetylcholine, an allergic reaction will occur. The clinical symptoms of cholinergic urticaria are mainly manifested as wind clumps, but the symptoms of wind clumps are not obvious, and the wind clumps fade quickly, within 24 hours, and the patient will only feel the obvious sensation of pins and needles and intense itching. For cholinergic urticaria, attention should be paid to avoiding triggers, such as avoiding hot drinks and spicy and irritating foods. When symptoms are found to be more serious, antihistamines can be applied, and drugs such as reserpine can be applied for treatment.