Adults with a fever of 38°C can, in principle, drink ibuprofen. Ibuprofen is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects, and can be used as antipyretic drug to reduce fever in acute fever, but it is necessary to clarify whether there are contraindications to the application of ibuprofen, such as allergy to non-steroidal drugs, aspirin allergy to asthma and pregnant and lactating patients, etc. Patients with a series of comorbidities such as gastrointestinal bleeding and cardiac insufficiency should also be considered as appropriate in accordance with the doctor’s instructions It should not be applied without authorization, and should be avoided in combination with other non-steroidal drugs and other drugs containing antipyretic and analgesic. The cause of fever 38℃ needs to be further clarified. Ibuprofen is only an antipyretic drug that cannot solve the root cause of fever, in this case fever over 38℃, it is better to go to a regular hospital for further consultation to further clarify the cause.