The pregnancy period of every pregnant woman is important, and especially the pregnancy period of pregnant women with hepatitis B has more ideas. How can pregnant women with hepatitis B spend their pregnancy safely? This article will explain in detail. During pregnancy, the burden on the liver of pregnant women increases, and fatigue, bleeding, surgery and anesthesia during delivery can aggravate liver damage. In addition, endogenous estrogen production increases significantly during pregnancy, and estrogen must be inactivated in the liver, which undoubtedly also increases the burden on the liver. In patients with cirrhosis, upper gastrointestinal bleeding is likely to occur due to increased plasma volume and cardiac output during pregnancy, and because the whole body is in a “diluted” state during pregnancy, the serum albumin level is relatively low, and edema, ascites and peritonitis are likely to occur. The burden of pregnancy on the liver increases with the number of weeks of gestation, and the risk of impaired or aggravated liver function increases. Therefore, it is important to test the liver function of pregnant women throughout pregnancy, usually every 1 to 2 months, and consult a specialist to deal with any abnormalities detected. In addition, liver specialists remind pregnant women to pay attention to the following points: 1, pay attention to rest and nutrition, especially when hepatitis is active more emphasis on bed rest, more high-quality protein diet, such as milk, fish, chicken, lean meat, etc., and a high vitamin diet, such as vegetables, fruits, etc. 2, must be under the doctor’s guidance of medication, especially before 12 weeks of pregnancy, because the fetus important organs are not yet mature, inappropriate use of medication is prone to fetal damage. In case of active hepatitis, the liver condition of the pregnant woman must be assessed. If only alanine transaminase is elevated and no jaundice is present, vitamin supplements can be given on the basis of rest and nutrition. If there is recurrent nausea and vomiting (excluding that it is an early pregnancy reaction), or jaundice or even ascites, hospitalization in a specialized hospital is mandatory. 3, due to the high susceptibility of pregnant patients to hepatitis E virus, infection with hepatitis E virus in mid to late pregnancy is prone to develop into severe hepatitis with a morbidity and mortality rate of 10% to 20%, at the same time, hepatitis E virus infection can contribute to the activity of hepatitis B and further aggravate the disease. Since hepatitis E virus is transmitted through the mouth, especially when eating unclean and uncooked shellfish, it is easy to be infected, so the intake of such food should be avoided. In conclusion, mothers-to-be with hepatitis B should seek more advice from a specialist when deciding to become pregnant, pay attention to liver function tests during pregnancy, and visit a specialist hospital for timely treatment once hepatitis activity occurs.