The common causes of painful urination in men are urinary tract infections, prostatitis, urinary stones and so on. The common cause of painful urination in men is caused by urinary tract infection, which manifests itself as frequent urination, urgent urination, painful urination, discharge from the urethra, and in some cases, the performance of hematuria. It is usually caused by local hygiene problems or unclean sexual life. It requires standard anti-infection treatment, drinking more water, and avoiding sedentary and holding urine. Men with painful urination have to rule out the possibility of prostatitis. When the prostate is invaded by external bacteria, resulting in local infection, there will be bacterial prostate inflammation, which will manifest itself in the form of urinary urgency and pain, and also lead to increased secretion of prostate fluid, some of which will manifest itself in the form of purulent secretions, a condition that requires the selection of quinolones or cephalosporin antibiotics for standardized anti-infection. The male urine pain, but also consider the possibility of urinary stones, urinary ultrasound examination to clarify, and then according to the different stone situation, choose a different treatment plan, small stones can be drug drainage, large stones need to consider extracorporeal lithotripsy or minimally invasive surgery to remove the stone. The painful urine in men suggests the possibility of many kinds of diseases, and it is important to seek medical attention in a timely manner, after a clear examination and targeted treatment.