Tenofovir belongs to the commonly used drugs for the treatment of hepatitis B. Its use is not recommended probably due to the existence of contraindications or the occurrence of adverse reactions. Tenofovir is commonly used clinically for the treatment of hepatitis B. However, if symptoms of adverse reactions such as severe headache, nausea and diarrhea, fatigue, dizziness and vomiting, rash or localized itching, and joint pain have occurred with previous use of the drug, reuse of the drug is not recommended. In addition, the use of the drug is prohibited in the presence of severe renal failure with creatinine clearance of less than 15 ml/min, severe hepatic impairment with liver function class C, hypersensitivity to the drug and its components, under 12 years of age, under 35 kg, and in the process of breastfeeding. The drug is also not recommended if there is resistance or cross-resistance to tenofovir, accompanied by kidney damage. There are many reasons why tenofovir is not recommended or is contraindicated; if a clinician explicitly advises against the use of the drug, it is recommended that the drug be used as prescribed.