Hepatitis B minor triple positive patients need antiviral if they have abnormal liver function and the virus is mutating and replicating actively. Hepatitis B minor triyang is the state in which the three items of hepatitis B e antibody, hepatitis B surface antigen and hepatitis B core antibody are positive in the human serology test of hepatitis B virus “two-to-half”. Hepatitis B minor triple Yang patients, if the hepatitis B virus has mutated, the virus is more active, still replicating in the body, at this time the virus is contagious, will make the patients have abnormal liver function, need antiviral treatment. The specific indications for antiviral treatment of hepatitis B small triple yang are serum hepatitis B virus DNA positive, gammaglutamylase persistent abnormality and exclude other causes; serum hepatitis B virus DNA positive compensated hepatitis B cirrhosis patients, hepatitis B surface antigen positive loss of compensated hepatitis B cirrhosis patients; serum hepatitis B virus DNA positive, gammaglutamylase normal. Liver puncture biopsy suggestive of significant inflammation or fibrosis; family history of hepatitis B hepatocellular carcinoma and age 30 years or older or hepatitis B cirrhosis; persistent normal alanine aminotransferase and age older than 30 years if significant liver fibrosis or inflammation is present; and extrahepatic manifestations associated with hepatitis B. Antiviral treatment is also recommended for those with one of the above conditions. Hepatitis B minor triple Yang patients should go to the hospital in time and follow the doctor’s instructions for treatment.