Early manifestations of chronic kidney disease include frequent fatigue, weakness;, edema of eyelids, face or lower limbs; large amount of foam in urine, blood in urine, too little or too much urine, increased nocturia; increased frequency of urination, inability to hold or painful urination; pain in the lower back and abdomen, etc. When renal insufficiency appears, various symptoms of chronic kidney disease gradually become obvious, such as pallor, fatigue, loss of appetite, nausea and vomiting, increased blood pressure, breath with urine smell, bone pain, itchy skin, drowsiness and unresponsiveness. Do not easily think that you are suffering from “hypertension”, “indigestion”, “iron deficiency anemia” or skin disease, dementia, etc., but must promptly conduct urine tests and kidney function measurements To avoid delays in diagnosis and treatment. The following symptoms should be examined at the hospital as soon as possible: 1, weakness, easy fatigue, lumbago, lumbago; because of busy work, fatigue, lumbago, lumbago, etc., there are very many phenomena, people often think that it is caused by work and fatigue. But it is worth reminding that lumbago may also be an early symptom of kidney disease. 2, the number of urination increased, can not hold, urethral pain. That is, doctors often say that the frequency of urination, urinary urgency, urinary pain, this symptom often suggests the possibility of urinary tract infection. 3, blood in the urine: can be the clinical manifestations of acute and chronic nephritis, but also urinary tract infections, stones, tumors caused. 4, urine foam increases and does not subside easily;: often indicates an abnormal increase in the excretion of protein in the urine. 5. Morning eyelid puffiness and lower limb swelling: including eye and face puffiness, facial puffiness, dorsal foot edema, ankle edema, and even generalized edema. 6. Too little or too much urine: If there is no cause for a large amount of sweating, fever, etc. that reduces the fluid content of the body, and a sudden decrease in urine volume occurs, see a doctor and have your urine checked to confirm the presence of kidney pathology, and likewise a steep increase in urine volume, you should also look for the cause of the increase in urine volume. 7, back pain: no clear cause of low back pain should go to the hospital to check the kidneys, spine and low back muscles and other conditions to clarify the cause, a type of chronic nephritis (1gA nephropathy) back pain is particularly obvious. 8, increased nocturia: normal people aged less than 60 years should not generally have nocturia, if young people have increased nocturia, it can be an early clinical manifestation of kidney malfunction, especially should draw attention to. 9, increased blood pressure; 10, unexplained anemia, itchy skin, cramps, bleeding gums, etc.; 11, unexplained loss of appetite, nausea, vomiting, etc.; renal failure manifestations: early renal failure can also be the same as kidney disease without special clinical symptoms, until the kidney function lost more than 50%, then some clinical manifestations may appear, when the kidney function is only 5 When only 5-10% of kidney function is left, the patient will be in advanced stage and clinical symptoms of uremia will appear, including pallor, lethargy, poor nausea, vomiting, itchy skin, especially confusion, coma, cramps or smell of ammonia in the mouth. Once clinical symptoms such as elevated blood pressure, anemia, poor appetite and nausea, increased nocturia, and itchy skin appear, do not easily think that you are suffering from “hypertension”, “iron deficiency anemia”, “indigestion”, or skin diseases. “It is important to pay attention to urine examination and kidney function measurement so that the diagnosis will not be misunderstood. Be on high alert for declining kidney function after the appearance of the following symptoms. These symptoms include: (1) decreased appetite and nausea; (2) bad breath; (3) pale face; (4) dry and itchy skin; (5) nighttime cramps; (6) weakness; (7) poor concentration, headache, and sleep disturbance.