With the development of economy, the improvement of living standard, the change of diet structure and lifestyle, the number of patients with biliary stones has increased dramatically. Repeated right upper abdominal pain may be accompanied by fever, jaundice, vomiting and other symptoms, and some patients may develop serious complications such as peritonitis and acute cholangitis. At present, the eradication of biliary stones still depends on surgery to solve the problem, while traditional surgery is inadequate due to trauma, slow recovery, and many complications. Patients suffering from the disease urgently need a minimally invasive surgical procedure that can cure the lesion with minimal trauma. Minimally invasive laparoscopic surgery requires only 3-4 small openings in the abdomen to complete the surgery, and the surgical incision can be healed by gluing with a band-aid, and the patient can move around in bed the same day after surgery and eat the next day. Female patients and elderly patients are more suitable for minimally invasive surgery because of their age and difficulty in withstanding the traditional major surgery. So which patients with gallstones are suitable for laparoscopic surgery? 1, gallbladder stones. 2, gallbladder infection or combined gallbladder stones. 3, gallbladder polyps or combined gallbladder stones. The above patients are suitable for laparoscopic cholecystectomy. 4.Gallbladder combined with common bile duct stones. Laparoscopic choledochotomy is one of the best surgical procedures for the treatment of common bile duct stones, which can achieve the effect of “killing two birds with one stone”. For simple common bile duct stones, EST (duodenoscopic sphincterotomy) can be performed first, and if it fails, then laparoscopic choledochotomy can be considered. 5, intra- and extra-hepatic bile duct stones. Laparoscopic choledochotomy is also feasible as long as the choledochoscopic lithotomy basket can reach them. After years of practice and summary, the minimally invasive surgical techniques of our department have been developed and rich clinical experience has been accumulated. The indications for surgery have been expanded, and patients who were not considered suitable for laparoscopic surgery in the past, such as acute cholecystitis, gallbladder neck stones, gallbladder stones combined with common bile duct stones, gallbladder atrophy, ceramic-like gallbladder, and history of upper abdominal surgery, are no longer contraindicated in our department.