Adenocarcinomas are a group of malignant epithelial tumors with adenoid structures or mucus secretion that occur mainly in the gastrointestinal tract, intrahepatic bile ducts, bile ducts (including gallbladder), lungs, female genital tract, and breast. If the tumor cells are too poorly differentiated and extremely immature, but still retain some traces of the tissue of origin, they are called hypofractionated, or grade III. Generally speaking, highly differentiated tumors, with low malignancy, have a better prognosis, low-differentiated tumors, with high malignancy, have a poor prognosis, and undifferentiated tumors, with extremely high malignancy, have the worst prognosis. So, what should be done to treat hypofractionated adenocarcinoma, which has a very high malignancy degree? First, let’s take a look at the common clinical treatment methods, which are: 1. Surgery. Surgery is the most important treatment method for hypofractionated adenocarcinoma, unless the tumor is clinically estimated to be unresectable and there are contraindications to surgery, surgery should be performed first. Surgery is the most important treatment for hypofractionated adenocarcinoma. However, since surgery can only remove the visible lesions and there are still a large number of residual cancer cells in the patient’s body after surgery, and it is more traumatic to the patient’s body and prone to complications and recurrence, it does not mean that everything is fine after surgery, and postoperative adjuvant therapy is still needed. Because radiotherapy has serious toxic side effects, it is recommended that patients choose mild and non-stimulating Chinese medicine for care, which can reduce the recurrence rate and improve the success rate of surgery. 2.Radiation and chemotherapy. It can be used as an adjunct to surgery or can act alone for patients who cannot undergo surgery. Through various rays or chemical drugs, it can quickly destroy cancer cells, control the patient’s condition and prolong the patient’s life. However, the treatment method of radiotherapy is “attacking poison with poison” and “quenching thirst with hemlock”, which will produce more toxic side effects while eliminating cancer cells and cause discomfort to patients. If used for a long period of time or excessively, patients may easily experience counterproductive effects. Therefore, when patients use radiotherapy, they must control the number of times and dosage to avoid overuse. It is best to carry out Chinese herbal medicine at the same time, which can play a role in enhancing the effectiveness of radiotherapy and reducing toxicity. 3, Chinese medicine treatment. Chinese medicine has been developed in China for thousands of years, which is not only rich in treatment concepts, but also tested by history. According to TCM, the development of hypofractionated adenocarcinoma is a systemic disease with specific reactions in human body parts. In the treatment process, we should start from the patient as a whole and achieve both the symptoms and the root cause by taking anti-cancer herbs. In clinical practice, many patients with hypofractionated adenocarcinoma prefer the “triple therapy”, which draws on the essence of Chinese medicine. 4.Integrated treatment of Chinese and Western medicine. Clinically, integrated treatment of Chinese and Western medicine is gradually developing as a trend in the treatment of ovarian cancer. Western medicine treatment focuses on local treatment and tumor-free survival, through surgery and radiotherapy, it can quickly and effectively control the patient’s condition. Chinese medicine focuses on comprehensive treatment, which can control the disease while regulating the balance of the patient’s internal environment to achieve both primary and secondary treatment. The combination of Chinese and Western medicine, with complementary advantages, is the key to reducing patients’ pain, prolonging their lives and increasing the cure rate.