Adenoid cystic carcinoma accounts for about 27% of the malignant tumors of the salivary gland. Due to its special biological characteristics and clinicopathological features, it cannot be removed by surgery alone, radiotherapy and chemotherapy are not sensitive, and biological therapy is still under experimentation. The new view is that certain malignant tumors are a chronic disease that requires emphasis on the quality of patient survival and improvement of survival with tumor, and adenoid cystic carcinoma is the best choice to achieve this treatment concept. Clinically, it was observed that γ-knife was effective in controlling lung metastases, and local radiotherapy using 125I radioactive particles, also γ-rays, made it possible to preserve tissue organs and vital structures. Radioparticle implantation therapy was adopted. Through template implantation, CT/MRI navigation, and pseudoreplantation, the patient’s tumor showed various degrees of shrinkage and symptoms could be relieved, achieving a perfect combination of tumor control and organ preservation, which could improve the patient’s survival quality. The main complications include radiation dermatitis and mucositis, pain, mouth opening restriction and radiation osteomyelitis. Due to the special requirements of patients for organ preservation of oral and maxillofacial tissues, 125I radioactive particle implantation is the preferred treatment for adenoid cystic carcinoma in this area.