OBJECTIVE: To investigate the efficacy and safety of combined tracheoscopic multiple interventions in adenoid cystic carcinoma of the airway (ACC). DATA AND METHODS: Thirty-seven cases of adenoid cystic carcinoma of the trachea (ACC) hospitalized from 2004.11 to 2012.3 with a mean age of 51.5±2.3 years were retrospectively analyzed. RESULTS: In this group, 97.3% of the patients had advanced stages (III+IV). the most frequently involved sites of ACC seen by CT were the middle and lower trachea and bilateral bronchial openings. Endotracheal type 5 patients (13.5%) received an average of 3.2±0.5 bronchoscopic treatments per case, including 1 rigidoscopic treatment per case; mixed type 32 patients (86.5%) received an average of 13.8±2.9 bronchoscopic treatments per case, including an average of 2.4±0.4 rigidoscopic treatments per case. All patients received more than 3 types of combined bronchoscopic interventions, including APC in 195 cases (mean 5.1±1.0 times/person), CO2 cryotherapy in 134 cases (mean 4.5±1.0 times/person), and cryotherapy combined with APC in 86 cases. There were 4 cases of bare metal stent placement, 14 cases of metal stent placement, 4 cases of PDT, and 10 cases of 125I radioactive particle implantation. Balloon catheter dilation was performed in 5 cases. After the first treatment of tracheoscopy, the lumen diameter was significantly enlarged, the KPS was significantly improved, and the shortness of breath score was significantly decreased. After six months of treatment, CR reached 32.4%, PR 54.1%, efficiency (PR+CR) 86.5, SD 13.5%, with a clinical benefit rate of 100%. The overall survival time of the patients was Conclusion: The combined application of multiple interventions in tracheoscopy can rapidly remove tumors in ACC airway and maintain airway patency, which is a safe and effective treatment method.