Most people know that obesity can lead to hypertension, hyperlipidemia, atherosclerosis, fatty liver, diabetes, stroke and other diseases, but they know little about the kidney damage caused by obesity. In fact, obesity damages kidneys through four pathways: high blood pressure, high blood sugar (diabetes), high blood lipid and high uric acid, while these four factors often affect each other, forming a vicious circle, which is medically called obesity-related nephropathy. Many obese people suffer from nephritis and uremia for no apparent reason, which should be given high priority. The kidney damage under high pressure Obesity can cause high blood pressure, high blood pressure, the blood vessels of the kidney will be under more pressure, like a rubber band, it needs a little elasticity, but if the blood pressure is always high, this rubber band will be pulled very tight. In the long run, the blood vessels will harden, and so will the kidneys. In addition to body obesity, a large amount of fat to the entire kidney to tightly wrap up, the formation of fat accumulation, resulting in poor circulation in the kidneys, the early stage can cause glomerular sclerosis, and later the entire kidney will appear a state of failure, atrophy, leading to the occurrence of uremia. High blood lipid kidney is injured Obesity easily causes hyperlipidemia, which leads to kidney damage, and its morphological changes are mainly the increase of kidney fat content, weight increase and volume increase; histological examination reveals that the basement membrane of renal tubules and glomeruli often have obvious fat droplets deposited, and glomeruli also become hypertrophic, which leads to focal segmental glomerulosclerosis. Diabetic nephropathy develops insidiously Obesity in old age easily leads to insulin resistance, which then leads to insidious diabetes mellitus. In particular, there are more women with obesity and non-insulin-dependent diabetes mellitus (type 2). The onset of the disease is insidious and the symptoms are not typical, usually without the typical symptoms of excessive drinking, urination and eating, and the occurrence of ketoacidosis is rare, while the occurrence of hyperosmolar coma is more common; however, some patients are apparently very robust, rosy, energetic and seem to be normal people, often with complications as the first symptom, and kidney damage is also its main complication. Hyperuric acid causes kidney damage Hyperuricemia is a disease caused by long-term disorders of purine metabolism and is very common in obese people. It manifests as recurrent acute arthritis, gout stone deposition, chronic arthritis and joint deformity, substantial renal lesions and uric acid stone formation. About 20-40% of patients may have intermittent small amounts of proteinuria in the early stages, and as the disease progresses, persistent proteinuria and microscopic hematuria may also occur. The urine is acidic, and there may be mild swelling and moderate benign hypertension. There is almost always a decrease in tubular concentration, with impaired tubular concentration preceding impaired glomerular function. The disease often progresses slowly leading to life-threatening renal insufficiency.