There is no clear clinical data indicating whether it is possible to take cetirizine for hepatitis B vaccination, but if cetirizine is taken for the treatment of certain underlying diseases, such as urticaria, allergic nasopharyngeal, eczema patients should not be vaccinated with hepatitis B vaccine, the above diseases are the contraindications for hepatitis B vaccination. If you need to take medication after hepatitis B vaccination, it is recommended that you consult your physician and do not take medication on your own. Cetirizine is an antihistamine drug, which is mainly used for the treatment of urticaria, allergic rhinitis, eczema, dermatitis and pruritus. Hepatitis B vaccine is mainly used for the prevention of hepatitis B, but for the existence of dermatitis, septic dermatosis, severe eczema, urticaria and other diseases, or penicillin, sulfonamide and other drugs allergies, should not be vaccinated against hepatitis B vaccine, allergies should not be vaccinated. If patients need to take cetirizine is to treat the above diseases, most should not be vaccinated with hepatitis B vaccine. And some patients can only be vaccinated after the disease is cured. Therefore, patients should choose to receive hepatitis B vaccine according to their own situation. If you need to take medication after the vaccination period, you need to consult a doctor in a regular hospital and choose the medication reasonably under the doctor’s guidance. It is recommended that patients understand the contraindications and precautions of hepatitis B vaccine before vaccination, and if they need to take medication, they should strictly follow the doctor’s instructions to choose the medication.