Malignant tumors metastasizing to the brain are often already at advanced stages and the treatment outcome is generally poor. With the development of modern neurosurgical techniques, as well as the advancement of new targeted drugs, immunotherapy and other drugs and technologies, the treatment outcome of metastatic tumors to the brain has been significantly improved than before. Among brain metastases, lung cancer is a common primary tumor. For tumors that metastasize to the brain, if they are large and have obvious occupying effects, or if the metastatic lung cancer in the brain is not sensitive to targeted drugs and chemotherapy, in many cases, surgery is also needed to remove the metastatic tumor lesions in the brain. For a single large metastatic lung cancer brain lesion, surgical resection can achieve better treatment results in most cases. However, for multiple lung cancer brain metastases, not all of them are suitable for surgical resection. Generally speaking, if there are only two or three metastatic lesions and the location of the lesions is relatively concentrated, surgery can remove all these metastatic lesions to the brain at one time, and can achieve similar results as one metastatic lesion removal. After lung cancer metastases to the brain, some patients can obtain better treatment results through surgical resection. Even if there are multiple tumors metastasized to the brain, after comprehensive evaluation by neurosurgeons, medical oncologists and radiologists, it is possible to achieve relatively satisfactory treatment results by surgically removing multiple metastases in appropriate patients.