Yellow runny nose in cold is usually a viral infection combined with bacterial infection, you can take pseudoephedrine hydrochloride and other relief of runny symptoms and amoxicillin and other antibiotics to fight infection. 1. Relief of runny nose symptoms: colds with runny nose, nasal congestion and other nasal symptoms, you can take oral compound pseudoephedrine hydrochloride extended-release capsules (narrow-angle glaucoma, epilepsy, mental illness, severe hypertension and other contraindications) and other medications, which can alleviate the symptoms of colds due to the runny nose, nasal congestion, sneezing and other symptoms. 2. Anti-infection: yellow nasal discharge in cold is usually combined with bacterial infection, which can be treated with antibiotics such as amoxicillin, cefaclor and other anti-infective drugs as prescribed by the doctor. The above drugs are prohibited for those who are allergic to them. If you have a cold with yellow runny nose and the symptoms don’t get better or new symptoms appear, it is recommended to consult a doctor in a timely manner, and you should use reasonable medication under the guidance of a doctor to avoid aggravating your condition.