The skull is a very important organ in the human body, serving as a hard barrier to protect the brain and head and face, as well as an important guarantee of a smooth operating environment within the skull. Therefore, if a cranial defect occurs, it should be treated promptly. What are the treatments for cranial defects? Cranial defects should be repaired as soon as possible at the right time. Usually, after the defect occurs, the skull repair can be performed after about three months of recovery from emergency treatment. Cranial repair is now a relatively routine surgery in neurosurgery, and there is basically no major problem technically, but mainly lies in the good or bad repair materials. At present, the titanium mesh material used by most hospitals has some less than ideal problems, such as the rejection of the titanium mesh causing exposure, various complications, such as the patient’s sensitivity to heat and cold after surgery, such as affecting the postoperative CT and MRI examinations, etc. Currently, our team is using the more advanced polyetheretherketone PEEK material for cranial repair, which has become the new favorite in the cranial repair world because of its excellent properties that are almost equivalent to human cranial bone and can achieve very good cranial repair results. Clinically, the application of this material has been a great success. It has become the preferred repair material for patients with cranial defects.