A high Cyfra211 suggests the presence of a lung tumor and may also be associated with diet, environmental factors, or other pathologies such as inflammation of the lungs or tuberculosis. Cyfra211 is a tumor marker to detect lung cancer. Lung cancer can be categorized into non-small cell lung cancer and small cell lung cancer, both of which can lead to high Cyfra211. Generally speaking, to consider the possibility of lung cancer, further lung CT examination is needed, and lung cancer is more likely to be suspected if occupancy is found by CT. Further percutaneous lung aspiration biopsy can be performed to clarify the nature of the occupancy. High Cyfra211 may also be related to diet, environmental factors or other lung inflammation, tuberculosis and other pathologies. Therefore, a high Cyfra211 is not enough to determine that it is a tumor, and it needs to be judged according to the specific value of the index and the patient’s other tests. Patients with high Cyfra211 should go to regular hospitals for diagnosis and treatment as soon as possible to avoid delaying their condition.