A major triple-positive person with hepatitis B virus can turn into a minor triple-positive person, which can be accomplished through lifestyle adjustment and medication. Major triple-positive refers to three positive hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B core antibody (anti-HBC), while minor triple-positive refers to three positive hepatitis B surface antigen (HBsAg), hepatitis B e antibody (anti-HBe), and hepatitis B core antibody (anti-HBC). So when hepatitis B e antigen turns into hepatitis B e antibody, the major triplet also turns into minor triplet, there are three ways: 1. Treatment with drugs: mainly antiviral therapy, including nucleoside analogues such as entecavir, tenofovir, propofol tenofovir, etc., alpha-interferon (IFN-alpha) such as common interferon and pegylated interferon, and other anti-inflammatory and liver-protective drugs such as silymarin preparations, glycopyrrolate preparations, and anti-fibrotic treatment drugs. and antifibrotic therapy drugs. It should be noted that not all patients need medication, and medication needs to take individualized principles, specific should follow the doctor’s instructions; 2, autoimmune: some patients are less severe, the virus carries or replicates less, the symptoms are not obvious, the body for immune modulation, there is spontaneous clearance of the virus and the possibility of transformation, so that the large triplet into a small triplet. In order to transform from major triple-positive hepatitis B to minor triple-positive through autoimmunity, attention should be paid to avoid overwork, a light diet, appropriate choice of high-protein, high-calorie, high vitamin diet and measures such as prohibition of smoking and alcohol, patients with obvious symptoms, heavy disease and jaundice should also rest in bed. The conversion of major triplets into minor triplets cannot be seen as a sign of improvement. In some cases, the hepatitis B virus mutates to become a minor triplet, but instead of decreasing, the condition worsens. After the conversion of major triplet to minor triplet, the status of DNA should be tested to determine whether the disease is decreasing or increasing.