Schizophrenia is a group of psychiatric disorders of unknown etiology, most often starting in young adults, with multiple impairments in perception, thinking, emotion, behavior, and incoordination of mental activities. There is usually no impairment of consciousness or intellectual deficits, and the course of the disease is often prolonged. Schizophrenia is highly relapsing and often requires long-term maintenance treatment with antipsychotics to prevent relapse. However, many people are concerned that long-term use of antipsychotic medications may lead to addiction, drug resistance, and reduced efficacy. Therefore, they often discontinue their medication on their own, leading to relapse of the disease. This is why it is quite wrong to think this way. Addiction is a condition in which the discomfort in the body occurs after stopping the drug and disappears after taking the drug. In order to seek the pleasure of taking the drug and avoid the painful experience of withdrawal, the patient compulsively takes a certain drug for a long time or periodically, which is medically called drug dependence or addiction. Years of clinical experience have shown that long-term use of antipsychotic drugs does not lead to dependence or addiction. However, long-term use of antipsychotic medications can produce withdrawal reactions when the medication is suddenly stopped due to the modulating effect on neurotransmitters. Therefore, it is not recommended to stop the medication suddenly, but to reduce the dosage slowly. Although long-term use of antipsychotic drugs does not lead to dependence or addiction and is relatively safe, psychiatric drugs, like other drugs, have side effects, so regular blood tests, liver function, kidney function, blood glucose, lipids and other indicators are needed.