Glomerulosclerosis and interstitial fibrosis are important factors affecting renal function in the elderly kidney, and the severity of glomerulosclerosis and interstitial fibrosis determines the state of renal function. The following factors play an important role in influencing glomerulosclerosis and fibrosis 1, high protein diet food protein intake more than 0.8 g/kg body weight / day, it can accelerate the glomerular hyperfiltration, hyperperfusion, so that the kidney reserve capacity significantly reduced, accelerating the glomerular sclerosis. And limiting protein intake can reduce or delay certain age-related kidney aging processes. Yu Dajun, Department of Nephrology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine 2, hypertension, diabetes: hypertension can increase the pressure in the small arteries and glomerular capillaries entering the kidney, causing glomerular hyperfiltration, thus accelerating glomerulosclerosis. Diabetes mellitus occurs in the elderly, and the glomerular filtration rate can be increased in the early stage of diabetes mellitus, so the increased detection rate of microalbuminuria in the elderly is more prominent in patients with hypertension and diabetes mellitus. 3, hyperlipidemia: atherosclerosis and disorders of lipid metabolism in the elderly are also involved in the process of glomerulosclerosis, and the accumulation of lipids in the kidney thylakoid cells with ageing promotes glomerulosclerosis. Lowering serum cholesterol can slow down the progression of kidney disease. 4, various renal diseases such as glomerular disease, tubulointerstitial disease, urinary tract infection, hyperuricemia kidney damage, drug-related kidney damage, etc., can aggravate renal damage in the elderly and cause kidney fibrosis.