Traditional craniotomy for cerebral hemorrhage can rapidly remove the hematoma and decompress the bone flap to save lives. However, it has a heavy strain on normal brain tissues, large trauma, edema reaction, and is not conducive to neurological recovery after surgery, with a mortality rate of 28%-48%. Although cone craniotomy is simple and easy to perform, it is poorly positioned, blinded during puncture and suction, and may cause excessive brain tissue damage and rebleeding. Although ventriculoscopy-assisted hematoma removal can be performed under direct vision, it is difficult to deal with intraoperative hemorrhage if it occurs. Using the principle of spherical design of the brain stereotactic instrument, we can choose the puncture route arbitrarily, avoiding the important neurological function area or vascular concentration area, so that the puncture needle can reach the center of the hematoma and the drainage tube can penetrate the long axis of the hematoma. Postoperatively, urokinase is injected to dissolve the hematoma to promote further drainage of the residual hematoma. Stereotactic minimally invasive drainage of the brain is simple, minimally invasive, and precisely positioned for patients with hypertensive cerebral hemorrhage. The incidence of rebleeding is very low and the neurological recovery is satisfactory.