The difference between rheumatoid arthritis and rheumatoid arthritis is mainly in the pathogenesis, clinical manifestations and treatment modalities. 1. Pathogenesis: Rheumatoid arthritis is closely related to hemolytic streptococcal infection, while rheumatoid arthritis is an autoimmune disease due to autoimmune disorders in human body. 2. Clinical manifestations: Rheumatoid arthritis mainly involves the large joints of the human body and causes corresponding pain, while rheumatoid arthritis mainly manifests symmetrical small joint pain, swelling and joint deformity. 3. Treatment: Rheumatoid arthritis is treated with long-acting penicillin against hemolytic streptococcal infection, while rheumatoid arthritis is treated with anti-rheumatic drugs such as methotrexate and leflunomide. All of the above medications need to be used as prescribed by the doctor. Rheumatoid and rheumatoid arthritis patients are advised to go to the rheumatology and immunology department of regular hospitals for detailed consultation and treatment as prescribed by doctors.