Headache caused by cervical spine muscle strain is considered to be caused by vertebral artery-type cervical spondylosis, which can be treated with Eperisone tablets, ibuprofen, methylcobalamin and other medications according to the specific condition and individual constitution. If the headache is accompanied by neck muscle spasm, it can be treated with Eperisone tablets. 1. Ethperisone Tablets: Muscle relaxants such as Ethperisone Tablets can relieve spastic muscles in the neck, thus improving headache symptoms. Adverse effects of Ethperisone tablets include drowsiness, indigestion, numbness of limbs, urinary retention, etc. It is forbidden for those who are allergic to the drug, pregnant women and lactating women. 2. Ibuprofen: Ibuprofen and other non-steroidal anti-inflammatory drugs have anti-inflammatory and pain-relieving effects, and have a certain degree of efficacy in headaches caused by cervical spine muscle strain. Adverse effects of ibuprofen include headache, stomach pain, dizziness, weakness of limbs, etc. It is forbidden for those who have peptic ulcer, pregnant women and lactating women, and those who are allergic to NSAIDs. 3. Methylcobalamin: cervical spine muscle strain may compress the nerve root causing radicular irritation headache, methylcobalamin is a neurotrophic drug, which helps to repair the nerve. Adverse effects of methylcobalamin include skin rash, headache, sweating, drop in blood pressure, etc. Methylcobalamin is contraindicated for those who are allergic to the drug. All of the above medications should be administered under the supervision of a doctor. If the patient’s above symptoms are serious, or the symptoms persist without improvement, he/she should go to the hospital in time for treatment.