Aminotransferase is one of the important indicators of liver function, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST). There are many causes of high aminotransferases. When we find elevated aminotransferases in laboratory tests, we should promptly seek medical consultation and carry out precise treatment after clear diagnosis based on medical history and other relevant laboratory tests and examinations under the guidance of professional physicians. If the aminotransferases are high due to non-pathological reasons such as fever, strenuous exercise, medication, alcohol consumption, etc., no special treatment is needed. If the aminotransferases are elevated due to liver lesions, the patient should improve the hepatitis virus series, liver ultrasound and other relevant laboratory tests and examinations to clarify the specific causes and then carry out precise treatment. For example, patients with fatty liver can undergo non-pharmaceutical treatments such as exercise and weight loss; patients with viral hepatitis should undergo timely liver protection, antiviral and other related treatments. If the patient’s transaminases are elevated due to other systemic diseases such as myocardial infarction, hyperthyroidism, myogenic injury, etc., the primary disease should be actively treated, and the patient’s organism can gradually return to normal after tissue damage. In conclusion, it is most important to consult a doctor in a timely manner when elevated transaminases are found, and to treat them accordingly after a clear diagnosis is made under the guidance of a professional physician.