Both glutathione and glutathione are important as enzymes required for amino conversion in the body’s metabolic process and as sensitive indicators of hepatocyte damage. Glutathione is mainly found in the cytoplasm of hepatocytes, while 80% of glutathione is found in the mitochondria of hepatocytes. If glutamic aminotransferase is elevated > glutamic aminotransferase, it is indicative of mitochondrial damage, which is persistent and more severe. In acute hepatitis, glutathione is significantly elevated, and the ratio of glutathione to glutathione is often <1. In chronic hepatitis and cirrhosis, glutathione is mildly to moderately elevated, and the ratio of glutathione to glutathione is often >1. If liver failure occurs, this may be manifested by a rapid decrease in glutathione and a persistent increase in bilirubin, suggesting massive hepatocyte necrosis.