Hands peeling cracking with blisters (blisters) may be ringworm, may also be sweat herpes, the treatment varies greatly, there are topical antifungal drugs, topical glucocorticosteroids, oral antihistamines and so on. 1. ringworm: caused by fungal infection of the skin of the hands, lesions can be manifested as blisters, flaking, cracking, accompanied by itching, fungal examination can be clear whether there is an infection, can be used externally antifungal drugs such as bifenbenzazole, miconazole cream, etc., the effectiveness of topical drugs is not good, can be taken orally antifungal drugs itraconazole capsule or terbinafine tablets. 2. Sweat herpes: also known as sweating not good eczema, lesions at the beginning of the blisters, broken or dry flaking, itching intense, can be used externally with glucocorticosteroids such as mometasone furoate cream, halometasone cream, etc., with the oral antihistamine chlortetracycline, levosulpiride, etc., the later flaking-based can be used externally with 10% urea cream. If the hand peeling cracking with blisters symptoms, it is recommended to go to the hospital as soon as possible, the doctor to develop a treatment plan, the drugs need to be used by the physician’s guidance, not self-medication.