Swollen and painful joints can be treated with medications such as non-steroidal anti-inflammatory drugs (NSAIDs), chondro-nutritive drugs, proprietary creams, and antibiotics, depending on the cause. Common causes include trauma, osteoarthritis, and infection. For joint swelling and pain caused by trauma, non-steroidal anti-inflammatory drugs such as ibuprofen and celecoxib can be used clinically for pain relief. It can also be treated by applying Chinese medicines that activate blood circulation and remove blood stasis, such as blood circulation and pain relief cream. For joint swelling and pain caused by osteoarthritis, drugs that nourish cartilage, such as glucosamine, can be used. If the arthritis is caused by bacterial infection, it can be treated with antibiotics, such as penicillin and azithromycin. In addition to medication, it can also be combined with localized hot compresses and other physical therapy to promote blood circulation, reduce edema, and promote the absorption of inflammation. There are many other causes of joint swelling and pain, if the joint pain symptoms are serious or persistent pain is not relieved, it is recommended to seek medical treatment as soon as possible, improve the examination to clarify the cause of the disease, and follow the doctor’s instructions to further standardize the treatment, so as to avoid delaying the condition. All of the above drugs should be used under the guidance of a physician.