Large granular lymphocytic leukemia is a type of acute lymphoblastic leukemia, the treatment of which begins with stratification of the patient’s risk level based on routine blood and bone marrow test results. It is generally divided into three types: low risk group, intermediate risk group and high risk group. For patients in the low-risk, intermediate-risk and high-risk groups, the beginning treatment phase is induction of remission therapy. The commonly used regimen is the VDLP regimen, whose chemotherapeutic agents include cyclophosphamide, vincristine, anthracycline chemotherapeutic agents, and glucocorticoids. After induction remission, consolidation therapy and maintenance therapy are also administered. Commonly used chemotherapeutic agents include 6-mercaptopurine and methotrexate. Regardless of the type of large granular lymphocytic leukemia, lumbar puncture with intrathecal injection is routinely required, with the aim of preventing the development of central nervous system leukemia.