Amniocentesis is one of the most important tests as a prenatal screening and is of great importance in reducing the number of children with congenital defects such as congenital stupidity and dementia. It has an indelible significance in reducing the burden on families and society. As an invasive test, amniocentesis is not necessary for all pregnant women. Generally speaking, it is recommended for pregnant women who are over 35 years old, have a high risk of Down’s syndrome screening or have a history of chromosomal abnormalities in childbirth. In fact, amniocentesis is not as scary as pregnant mothers think, it is just like a normal intramuscular injection, but for pregnant women with fever, pre-eclampsia, or an overly sensitive uterus, there is a risk of infection and miscarriage. For the fetus, amniocentesis is performed under ultrasound, not “blind”, and the period of amniocentesis is chosen when the fetus is relatively small and the amniotic fluid is large, with a large pool of amniotic fluid around the fetus, which greatly protects the fetus. To reduce the risk of amniocentesis, it has strict contraindications, after all, we are only doing it to screen for risk. Patients who have had a pre-eclampsia, a temperature above 37.5°C, signs of pelvic or uterine infection, a tendency to bleed or abnormal coagulation, for example, will not have an amniocentesis until their bodies are in optimal condition. It is important to note that although amniocentesis is simple and easy to perform, it is, after all, an invasive operation and some risks are inevitable. Amniocentesis is not mandatory, but for the health of the next generation, doctors recommend it to avoid regrets in the future.