Liquid nitrogen or carbon dioxide dry ice freezing causes necrosis of the wart tissue (i.e., localized skin damage). Condyloma acuminatum is a benign proliferation of the skin mucosa due to infection by the condyloma acuminatum virus. It has a large number of small blood vessels and proliferates rapidly. The use of freezing causes ice to form within the condyloma acuminatum, creating a high degree of localized edema of the tissue and thus destroying the wart. The biggest advantage of cryotherapy is that it leaves no local traces and the cure rate is about 70%, but the recurrence rate is high. Local redness, swelling, pain and blistering can occur during treatment. It can be done by spray or direct contact method and is suitable for flat and small warts. It is usually frozen once a week for 2 to 3 times.