Unilateral hemilaminectomy microsurgery for intravertebral lesions is gradually being recognized and advocated as a way to maximize postoperative spinal stability with the advantages of minimal trauma and definitive efficacy. Methods: Preoperative CT examination of the vertebral body was performed to understand the vertebral body, arch, spinous process, and articular eminence, and to assess and design the surgical approach. The unilateral paravertebral muscles were surgically separated and the hemilaris and sphenoid roots were removed, leaving the supraspinous ligament, sphenoid body, interspinous ligament and articular eminence intact. All procedures were performed under a microscope. After surgery, the paravertebral muscle was sutured to the interspinous ligament and the supraspinous ligament was intermittently sutured. The patient was discharged from bed the day after surgery and discharged from the hospital 4-7 days after surgery. The operative time, intraoperative bleeding, complete tumor resection rate and average postoperative hospital stay, improvement of clinical symptoms), improvement rate, postoperative spinal stability, and occurrence of complications were evaluated. Hemilaminectomy microsurgery for intravertebral disease has the advantages of less trauma, shorter operation and hospitalization time, less intraoperative bleeding, and exact efficacy, which can maintain the stability of the spine after surgery to the maximum extent and strictly control the indications for surgery, with satisfactory clinical results, and is worthy of clinical promotion and application.