Duodenal bulb ulcer belongs to the upper gastrointestinal tract ulcer, drugs can choose H2 receptor antagonists or proton pump inhibitors to inhibit the secretion of gastric acid, at the same time, auxiliary use of peptic mucosal protective agent drugs. 1. Acid inhibitors: commonly used H2 receptor antagonists such as ranitidine, famotidine, cimetidine, and proton pump inhibitors such as pantoprazole, rabeprazole, lansoprazole. 2. Gastrointestinal mucosal protectants: common ones are aluminum thioglycollate gel, teprenone capsule and so on. 3. Usually patients with duodenal bulb ulcers are often accompanied by Helicobacter pylori infection, therefore, patients with clear combination of Helicobacter pylori infection need eradication treatment. After eradication of H. pylori, duodenal bulb ulcers can generally achieve clinical cure and rarely recur. Surgical treatment is often required for bleeding ulcers that have failed conservative medical treatment and for acute perforation. Duodenal bulbous ulcers can be cured only after regular examination and treatment, once such condition occurs, it is necessary to go to the regular hospital for examination and treatment, do not self-medication, so as not to delay the condition.