Brain metastasis of malignant tumors has long been regarded by the medical community as one of the criteria for judging the advanced stage of tumors. Once a patient is found to have brain metastases, it means that the patient has entered the end stage of the disease. Patients are even more frightened and waiting for death. However, the clinicians fighting in the front line of tumor treatment have not given up their efforts. The ever-improving imaging technology detects the tiny metastases in the brain earlier; the ever-improving radiation technology (linear gas pedal, X-ray knife, gamma knife) and new chemotherapeutic drugs and targeted drugs allow patients with brain metastases to have more treatment opportunities; some patients with single or resectable multiple metastases have been given the chance to be cured by surgery. Some patients with single or resectable multiple metastases have been given the opportunity for surgical treatment, and some patients have achieved long-term survival (more than 10 years). Although brain metastases may occur in a variety of malignancies, the most common types are those that occur in lung cancer, breast cancer, and malignant melanoma, while other histologic types are less common. In particular, brain metastases occurring from lung cancer account for almost a large proportion of all brain metastases, with lung adenocarcinoma and small cell carcinoma being more common. Brain metastases from lung adenocarcinoma account for approximately more than 50% of all brain metastases. Studies have shown that lung cancer is neurotropic in nature and is highly susceptible to neurological metastases. Therefore, once an occupying brain lesion is detected clinically, a chest CT examination must be performed promptly. Conversely, patients with lung cancer should also undergo brain MRI promptly if lung cancer is detected. Treatment: Intracranial metastases are difficult to treat, and most of them are mainly treated with comprehensive treatment, such as surgery supplemented by radiation therapy (including gamma knife, X-knife, radiofrequency knife, etc.) and chemotherapy, which can relieve patients’ symptoms and prolong their lives. The specific treatment method generally needs to be considered according to the patient’s age, general condition, neurological function, primary tumor site and treatment, the presence of multiple metastases outside the brain, and the number, size and location of brain metastases. Surgical resection of brain metastases is an important means to improve the prognosis of patients. The indications for surgery include: a single solid tumor, especially if the maximum diameter of the tumor is more than 3 cm or the midline shift is more than 1 cm; multiple tumors, but there is a clear responsible lesion that is considered to cause serious clinical symptoms, life-threatening or resectable multiple lesions; the patient has a stable primary tumor and the expected survival is more than 3-6 months; the patient is in good general condition, without malignancy and severe liver and kidney dysfunction. All these cases can be selected for surgical resection. In patients with superficial tumor sites, non-critical functional areas, no serious systemic diseases, acute intracranial pressure elevation and newly diagnosed brain metastases, surgical treatment of single brain metastases has become an important part of the standard treatment plan. Surgical treatment includes tumor resection and palliative or decompressive surgery. For single brain metastases, tumor resection can be performed if the general condition is good, the primary tumor has been resected, and no other metastases are found. If the primary tumor has not been resected but can be removed, and the brain symptoms, especially the symptoms of increased intracranial pressure, are significant, brain tumor resection can be performed first. After the increase of intracranial pressure is relieved, resection of the primary tumor can be performed again. When removing the tumor, it is generally easy to separate from the brain tissue, and the scope of resection should be more extensive, striving for total resection. If the tumor site is deep or multiple tumors, as well as meningeal metastasis, decompression surgery can be performed to reduce the symptoms. The most important advantage of surgical resection is that it can quickly relieve the neurological symptoms caused by brain tissue edema, stroke, various occupying effects caused by lesion compression and elevated intracranial pressure, so that the local lesion can be effectively controlled and the quality of survival can be effectively improved. For those with unresectable primary tumors, multiple metastases in the body and very poor general condition, surgery is not recommended. Symptomatic treatment such as hormones and dehydrating drugs can be given, which can relieve symptoms for a short period of time. Radiation therapy is an important treatment method for brain metastases, especially for cases with multiple intracranial metastases; those with single metastases who have good general condition and normal blood picture after surgery; those with single metastases but located in important functional areas that cannot be removed surgically; tumors that are not suitable for surgery but sensitive to radiotherapy, such as nasopharyngeal tumors. Some scholars have reported that surgery combined with whole brain radiation therapy can prolong survival, reduce the rate of local recurrence and prolong the time of self-care. In the past, it was thought that most chemotherapeutic drugs were difficult to cross the blood-brain barrier to exert therapeutic effects, and chemotherapy was not considered as the preferred treatment for brain metastases. However, in recent years, with the advancement of clinical research, the emergence of new small molecule chemotherapeutic drugs and targeted therapeutic drugs, which can cross the blood-brain barrier, and some other studies have confirmed that the blood-brain barrier can be opened under the induction of some factors, chemotherapy for brain metastases is still useful. Especially for those patients with systemic multiple metastases, chemotherapy is the main treatment tool. Chinese medicine treatment:For cancer patients are weak, they can be combined with Chinese medicine in the treatment process to reduce the pain of western medicine treatment and accelerate the recovery of patients’ body. Molecular targeting therapy: It is to design the corresponding therapeutic drugs at the cellular molecular level, targeting the defined oncogenic site (the site can be a protein molecule or a gene fragment inside the tumor cell), and the drugs will specifically select the oncogenic site to combine with it to cause the specific death of tumor cells without affecting the normal tissue cells around the tumor. Targeted therapy is also called “biological missile”. Currently available targeted drugs include gefitinib, erlotinib, erlotinib and bevacizumab. Immunotherapy: CLS biological cell therapy is a method to stimulate and enhance the body’s own immune function by using biotechnology and biological agents to culture and amplify immune cells collected from patients in vitro and then transfuse them back into the patient’s body to achieve the purpose of tumor treatment. CLS cell therapy can not only effectively restore and strengthen its immune anti-tumor effect, but also increase the radiosensitivity of cancer cells, completely eliminate the residual cancer cells in the body, reduce the recurrence and metastasis of tumor, and have high cure rate.