The side effects of Eszopiclone and Dexzopiclone cannot be directly compared, the occurrence of adverse reactions varies from person to person, and it is not possible to generalize and consider discontinuing or reducing the medication in case of side effects. It is recommended to use the drug properly under the guidance of a medical professional. Common adverse reactions to Eszopiclum include dry mouth, drowsiness, dizziness, and fatigue, and high doses can cause ataxia and tremor. A small number of users may experience adverse reactions such as rash, leukopenia, euphoria, polyphasia, and sleep disturbances. The common adverse effects fade away after prompt reduction or discontinuation of the drug. If the side effects are severe or impair the immune system, then immediate medical attention is recommended. It is contraindicated for people who are allergic to the product and the ingredients contained in it, patients with hepatic or renal impairment, patients with myasthenia gravis, patients with acute or easy onset of angle-closure glaucoma. It is not suitable for pregnant and lactating women, children under 18 years of age. The main side effects of dexzopiclone are manifested by symptoms such as bitter mouth, dizziness, drowsiness, weakness, nausea and vomiting, which are usually mild. The drug is contraindicated in people who are allergic to the product and the ingredients contained in it, patients with decompensated respiratory insufficiency, myasthenia gravis, and patients with severe sleep apnea syndrome, as it can cause serious consequences such as asphyxia or respiratory arrest. Pregnant and lactating women, children under 18 years of age should not use it. When choosing sleep-improving drugs for treatment, you need to consult your doctor first and follow the doctor’s instructions to use them according to the reasonable dosage. In case of adverse reactions or physical injury, it is recommended to adjust the medication in time.