Some patients may be asymptomatic for a long time, but serum protein electrophoresis reveals monoclonal immunoglobulin (IG) peaks or positive light chains in urine, which is called “pre-myeloma”. The most frequently invaded bones are the skull, ribs, sternum, vertebrae and the proximal ends of the long bones of the limbs, as the infinite proliferation of myeloma cells in the bone marrow cavity leads to diffuse osteoporosis or limited bone destruction. In weight-bearing areas there are often several fractures occurring at the same time last X-ray examination can especially find typical multiple osteolytic lesions diffuse osteoporotic pathological fractures etc. can help in the hygienic diagnosis. The clinical scientific manifestations related to M protein are as follows: ① urine protein about ~% of myeloma patients appear in the urine light chains of Ig called Bence Jones’ protein system because the Ig molecules synthesized by the tumor cells have more light chains than heavy chains and the light chains are small molecules that can be filtered from the glomerulus and appear in the urine when the amount of light chains is small and not easily detected by concentrated urine for electrophoresis. ②Blood sedimentation rate increases to more than mm in the first hour. ③ bleeding tendency thrombocytopenia and M protein-induced blood flow stagnation vascular wall damage platelet and coagulation factor dysfunction patients often have bleeding tendency manifested as mucosal bleeding skin purpura late stage may have internal or intracranial bleeding with serious consequences. ④ Renal failure due to the deposition of light chains in the renal tubules hypercalcemia and hyperuricemia so that the renal tubular reabsorption is impaired by the infiltration of tumor cells into the kidney and other reasons excellent chronic renal insufficiency is a significant feature of the disease has been one of the late course of the disease uremia can become the cause of death in the University. ⑤ susceptible to infection normal Ig content is reduced often leads to immune tutor dysfunction patients often have recurrent infections to lung and urinary tract infections are more common. ⑥High viscosity syndrome contributes to a large number of monoclonal Ig to increase blood viscosity to slow blood flow causing microcirculatory disorders retina brain kidney and other organs are particularly susceptible to damage causing dizziness visual impairment hand and foot numbness and other symptoms can lead to coma when the brain function is seriously affected this syndrome is mostly seen in IgM type myeloma and macroglobulinemia. (7) Raynaud’s phenomenon some patients with monoclonal Ig is cold precipitated globulin when cold globulin agglutination precipitation caused by microcirculatory disorders appear hand and foot cyanosis cold numbness or pain and other phenomena after heat symptoms relief. (8) Amyloidosis a few patients with amyloidosis amyloid material widely deposited in the core tissues and organs and tumors causing peripheral nerve kidney heart liver and spleen lesions leading to hepatosplenomegaly joint pain nerve function abnormalities and other clinical expertise.