The presence of high bilirubin in newborns may be a clinical symptom of many diseases, and excessive bilirubin accumulation will cause the skin and mucous membrane to become yellowish in color. The main cause of hyperbilirubinemia in newborns is excessive bilirubin production, such as delayed umbilical cord ligation, intrauterine hypoxia, bleeding, infection, blood type incompatibility, breastfeeding and other conditions can cause hyperbilirubinemia. 2, liver bilirubin metabolism abnormalities, hypoxia infection can inhibit liver enzyme activity, causing high bilirubin, in addition to certain drugs and congenital hypothyroidism and other reasons can also lead to liver metabolism of bilirubin decline, and cause jaundice. 3, in addition, increased bilirubin is also seen in bile excretion disorders, for newborns, such as hepatitis, biliary atresia, etc. will affect the bilirubin excretion, will also cause hyperbilirubinemia There are some rare cases, or early detection and early treatment, is to affect the development of the baby’s intelligence or motor system, and in serious cases can be fatal. Regardless of which condition induces hyperbilirubin, it is recommended that the standard treatment be explained as soon as possible, otherwise it may cause some sequelae for the newborn.