Hepatitis B interferon can be stopped once it has been given, but it should be stopped after meeting the criteria for stopping the drug and under the guidance of a doctor. Hepatitis B interferon, as a commonly used drug for the treatment of hepatitis B, has antiviral, antifibrotic and immunomodulatory effects. Its main treatment target is HBV-DNA and HBeAg positive chronic hepatitis B patients, the principle of drug action is to inhibit viral replication, improve liver function, reduce liver inflammation and fibrosis, so as to prevent the occurrence of cirrhosis and hepatocellular carcinoma. Clinical criteria for stopping hepatitis B medication is that the patient’s HBV-DNA becomes negative and liver function returns to normal for more than half a year before hepatitis B patients can stop taking the medication under the guidance of a professional doctor, and after stopping the medication, they should also do a good job of regular testing. If you stop taking the medication blindly, it is easy to cause the condition to rebound and even deteriorate. In addition, even after reaching the standard of stopping medication, hepatitis B patients also need to pay extra attention in life, try to avoid overwork, avoid smoking and alcohol, maintain emotional stability, do not abuse drugs to increase the load on the liver. When the body appears uncomfortable, you need to consult a doctor in time.