Patients with advanced ankylosing spondylitis also need to adhere to reasonable and effective treatment to control their symptoms and maximize their quality of life. Medications are usually available, such as meloxicam or celecoxib and other NSAIDs, which have the effect of treating joint pain and morning stiffness. Of course, it is also important to pay attention to adverse reactions, mainly gastrointestinal reactions may occur, which may lead to allergic reactions, etc. In addition, it is important to combine anti-rheumatic drugs that improve the condition, choosing lorazepam combined with thalidomide, and also applying methotrexate, ralteon, leflunomide, and elamod. Biological agents or glucocorticoids can be used to control the condition. For patients who develop severe hip stiffness and severe spinal deformities, surgical treatment is required.