Why prostate cancer still occurs after prostatectomy is divided into the following two main conditions:
- After radical prostatectomy for prostate cancer, local manifestations of prostate cancer or distant metastatic lesions are found again, which is the recurrence of prostate cancer after radical prostatectomy.
- Benign prostatic hyperplasia leads to urinary obstruction and difficulty in urination and prostate surgery, such as the common transurethral electrodesection of the prostate, plasma electrodesection/enucleation of the prostate, and various types of laser vaporization/enucleation, because the surgery for prostatic hyperplasia removes only the hyperplastic part of the gland and the prostate envelope is still preserved during the surgery, then the remaining prostate gland and envelope may still be cancerous.

Because the preferred site of prostate cancer is itself the peripheral zone of the prostate which is the equivalent of the prostate envelope, prostate cancer can still occur after surgery to remove the prostate gland for prostate enlargement.