OVERVIEW
Overview of Pseudogranulocytopenia
Pseudo-granulocytopenia is the result of an abnormal distribution of granulocytes, with an increase in the number of walled granulocytes resulting in a decrease in circulating granulocytes. Neutrophil counts may rise to normal or one to two times the pre-test count after epinephrine injection.
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Department
Pediatrics
Clinical symptoms
No obvious clinical symptoms or non-specific manifestations such as dizziness, malaise, low-grade fever and pharyngitis. Different parts of the infection may present with corresponding symptoms.
Hazards
Severe infections are prone to develop into septicemia with high mortality rate.
Complications
Septicemia, etc.
Examination
Bone marrow image analysis, blood image analysis, exercise test, adrenaline test, blood routine, etc.
Diagnosis
Diagnosis can be made on the basis of recurrent infections, clinical history and medication history combined with the results of exercise test and epinephrine test.
Treatment principle
Generally, the disease is mild and does not require special treatment. Treat the primary disease for the cause, prevent secondary infection, and transfuse fresh blood appropriately.
Curative
If the acute onset of the disease is caused by drugs or radioactive injury, the patient can be cured after stopping the drugs and rescue treatment.
Dietary recommendations
Eat high heat flow, high protein, easy to digest food.
Important Reminder
Failure to control acute severe infection in time may result in death of the patient.
Etiology
Etiology
Autosomal dominant genetic predisposition is found in some families, and there can be predisposing factors, such as infections, aminopyrine drugs, prolonged use of glucocorticoids or radiation injury, autoimmune diseases; mood changes, exercise, changes in body temperature, and injections of epinephrine can lead to abnormal distribution of granulocytes.
Symptoms and Diagnosis
Typical Symptoms
The clinical symptoms of neutropenia due to various causes are similar, depending on the degree of neutropenia, and the onset of the disease may be rapid or slow. Acute onset of the disease is rapid, and is often complicated by severe infections or sepsis in the lungs, urinary tract, skin, oral mucosa and skin, with symptoms such as high fever, chills, malaise and mucosal ulceration. The chronic process is accompanied by low fever and malaise. Due to the compensatory function of the organism, some patients have no obvious symptoms and may not have infections, and the general course is good, which can be relieved by itself with age.
Diagnostic basis
The patient has recurrent infections. Some patients have family history of the disease and history of drug use. Exercise test if granulocytes are decreased on examination before exercise and increase to normal after exercise. Epinephrine test, neutrophil count after injection of epinephrine may rise to normal or 1-2 times the pre-test count. The diagnosis can be confirmed. The results of blood and bone marrow image analysis assist in the diagnosis.
Treatment
Treatment guidelines
Pseudo-granulocytopenia does not require special treatment, but should be treated according to the cause with appropriate anti-infective and anti-allergic treatment.
Drug treatment
Apply appropriate antibiotic treatment in case of infection. Anti-allergy treatment.
Prognosis
Prognosis is good, often can survive for a long time, generally mild, do not need special treatment, intermittent episodes, moderate reduction of granulocytes, the process is good, with the growth of age, can be relieved on their own.
Nursing care
Daily care
Pay attention to personal hygiene, avoid infection, strengthen physical exercise, improve their own resistance.
Diet
Eat more nutritious and easy-to-digest and absorb foods, avoid stimulating foods.