The blood type of a Zhuang couple in Guangxi is O, but the blood type report of their newborn baby shows B, which is not in accordance with the law of blood group inheritance. Chinese immunohematology and genetics researchers found after research that the baby was indeed the couple’s biological flesh and blood, and uncovered the mystery of Zhuang-specific blood group genetic inheritance characteristics. O blood type parents B blood type baby In October 2007, a Zhuang couple from Shanglin County, Guangxi, gave birth to a male baby at the Third People’s Hospital in Nanning City. They were delighted to find that the baby’s blood type was reported as B, while the couple’s blood types were both O. It is common medical knowledge that a couple with type O blood cannot give birth to the next generation with type B blood. This made the baby’s father doubtful: Is the child not related to himself by blood? Asking his wife, she replied with certainty: “It’s your biological son.” Then could it be that the child was held by the hospital by mistake? The couple asked the hospital, which said there was no such possibility. The hospital conducted another blood test on the child, and the results still showed that the baby’s blood type was B. The results showed that the blood type of both husband and wife was O, and the blood type of the baby was B, which was consistent with the hospital’s test results. The results of the paternity test later showed that the baby was indeed the biological flesh and blood of the husband and wife. Why did the parents with O blood type give birth to a baby with B blood type? At this point, some people in the medical community suggested that it was possible that one of the parents had a rare genetic predisposition that caused the child to have a genetic variation. The strange genetic inheritance created a mystery Blood type test showed that in addition to the baby’s father’s blood type “O”, the baby’s grandparents and two aunts were all B blood types. Professor Wu Guoguang, a Chinese expert in immunohematology and genetics, led the researchers at the Nanning Institute of Blood Transfusion Medicine to find that the baby’s father’s O blood type was only a false appearance, but was actually a bizarre B blood type. He had a B blood type from his parents, but this B blood type could not show up and could not be found in routine tests because the two H genes that helped generate it were a specific H gene that had lost its function. The researchers found that the baby’s grandparents were both B-types and each had one of these specific H genes, and the baby’s father happened to “pick up” the H gene from both parents, and with the combined effect of the two specific H genes that could not produce a B type, the baby’s father took on the false appearance of an O blood type. In this way, he has a B baby with his wife, who is a true O type. The baby and his grandparents, on the other hand, do not affect the appearance of their B blood type because each has only one trait H gene O blood type parents B blood type baby. The mystery of the existence of the specific blood group gene, this specific H gene, is very rare in international academic reports, like the baby’s father with two such specific H genes at the same time, which has not been found in the medical community before. Researchers at the Nanning Institute of Transfusion Medicine finally uncovered the mystery after a six-month study in which more than 1,000 cases of blood were randomly sampled and analyzed in the Guangxi Zhuang population. They found that this specific H blood group gene, which has a certain distribution in the Zhuang population, is a characteristic of the blood group of the Zhuang population in China that has not been reported internationally so far, and its role and biological function are under further study. As a world-renowned expert in immunohematology and genetics, Prof. Guoguang Wu is currently leading the 14th International Society for Platelet Transfusion Immunology Seminar in Nanning, Guangxi. The findings of Prof. Wu and his research team have attracted a lot of attention from the international academic community. According to Guoguang, this discovery further confirms that the genetic structure of the blood groups of Chinese ethnic groups may have certain differences and characteristics. Its discovery not only clarifies the fact that the baby’s family is related by blood for three generations, but also contributes to the development of blood transfusion and blood safety treatment for Zhuang population as well as ethnology and forensic medicine through the understanding of the blood group characteristics of Zhuang population, and at the same time, contributes to the research of international blood group theory and the development of related academics.