The terminal symptoms of multiple myeloma mainly include the following: 1. Severe anemia: severe anemia, including severe weakness, requiring repeated multiple blood transfusions, severe thrombocytopenia, or coagulation dysfunction, which causes bleeding, including repeated bleeding in the gastrointestinal tract, and even causing brain bleeding; 2. Bone pain: bone pain is a characteristic of multiple myeloma, including pain in the thoracic, lumbar, and sacral spine, rib The patient cannot turn over or get up, or even experience pain in the long bones, including the tibia, fibula or humerus, etc. Bone pain is a symptom of severe infection. Insufficiency: in severe cases, symptoms such as heart failure can occur. Multiple myeloma is a common malignant tumor of the hematological system, accounting for the second highest incidence among hematological malignancies. It is a malignant disease of plasma cells, characterized by abnormal proliferation of bone marrow plasma cells accompanied by an abnormal increase in monoclonal immunoglobulin, or M protein. However, a small proportion of myeloma does not have monoclonal immunoglobulins and is called the nonsecretory type.