The causes of diffuse goiter are different and the treatment methods are different: 1. Simple goiter, depending mainly on the cause of occurrence, such as low iodine and endemic goiter, can be prevented and treated with iodized salt or iodized oil; for physiological enlargement, most enlargements are not significant and generally do not require special treatment; for patients with congenital disorders of thyroid hormone synthesis, the main thing is to give thyroxine, thyroid tablets, early. For patients with congenital disorders of thyroid hormone synthesis, the main treatment is early administration of thyroxine and thyroid tablets, which are not physiologically sufficient to reduce goiter.2. For nodular goiter, the treatment plan should be selected according to the benignity and malignancy of the nodule and thyroid function.3. For toxic diffuse goiter, medication, surgery, and isotope therapy can be used.4. For Hashimoto’s thyroiditis, hormone therapy can be used for enlarged thyroid gland with pressure symptoms; for those with hypothyroidism, thyroid hormone replacement therapy can be used; for those with transient For hyperthyroidism, symptomatic and low-dose oral therapy with insulin can be used. 5. For subacute thyroiditis, if the symptoms are mild, non-steroidal anti-inflammatory drugs can be used to control the symptoms; for heavy symptoms, hormones can be used; for hyperthyroidism, β-blockers can be used for symptomatic treatment. In short, treatment measures should be taken according to the cause of diffuse thyroid lesions and whether they are combined with abnormal thyroid function.