Azoospermia is one of the most important factors of male infertility, the incidence of which has been increasing in recent years and is a crisis of men’s physical and mental health. Azoospermia refers to the failure to find a single sperm in the ejaculated semen for three consecutive times. Azoospermia has caused deep suffering to patients and numerous problems to doctors. Azoospermia accounts for about 15-20% of male infertility patients. In addition to infertility, there are no clinical signs and symptoms. What are the causes of male azoospermia? The following we will look at, azoospermia is divided into two categories, one is because the testes themselves sperm dysfunction caused, is equal to no product processing plant, so there is no product supply; the second is the testes sperm function is normal, can produce qualified products, but due to the obstruction of the vas deferens, so that the testes generated sperm can not be discharged from the body, this situation is called obstructive azoospermia. The common causes of testicular spermatogenic dysfunction are: 1. Azoospermia: The testes are the only place to produce sperm, and without the testes, sperm is not available. Since there is no testicle, there is no treatment value; 2. Bilateral cryptorchidism: This condition is a case where the testicle does not go to the scrotum where it should be and stays in the abdominal cavity because the temperature is much higher than the scrotum, there is no way for sperm to be generated at all and azoospermia can also occur. This condition can be treated surgically, and it should be noted that the earlier the treatment, the better the results; 3. Congenital varicocele dysplasia (also known as Kline-Felter syndrome): this is also a developmental cause, although there is no problem with the location of the testicles, but the same problem exists with sperm production. The condition is not very serious if found in time, and there is hope for treatment; 4. Viral orchitis triggered after mumps, and testicular tuberculosis, etc.: This condition is a case of acquired damage to the testicles, which infringes on their sperm-producing function, and there will also be no sperm or very little sperm. In such cases, the key is prevention, once the infection factor is found, the cause should be promptly dispelled to prevent the disease from aggravating; 5. Genital injury: external injury leading to testicular injury or torsion, spermatic cord torsion, etc., or trauma due to hernia repair surgery, prostate surgery, etc., can also affect testicular function and lead to sperm production disorders. This situation is mainly prevention and timely and effective measures; 6, radiation exposure: sperm is very fragile, if in the presence of powerful electromagnetic waves, radiation, will be met with extinction. The cause is only good prevention; 7, testicular local high temperature: frequent, long time hot bath, sauna, or other factors caused by the testicular temperature increase, will affect sperm production, but most of such cases are less sperm, too much sperm death, etc.. Avoid all factors that increase the temperature of the testicles; 8, consumption of cottonseed oil: the oil contains a component called cotton phenol, this component can inhibit sperm production, so people use male contraception, but if men who intend to have children eat more, it will happen that the sperm will be reduced or even disappear. If you eat too much cottonseed oil, it is difficult to return to normal after stopping; 9, varicocele: this condition can seriously affect the blood supply to the testes, which in turn affects the spermatogenic function of the testes, will also occur a large reduction in sperm or even disappear. Timely surgery or medication (for mild cases) can be expected to restore the reproductive function of most patients; 10, hypogonadism: it can also be seen clinically, only less often. The main causes of obstructive azoospermia are: congenital bilateral vas deferens; reproductive duct injuries, such as urethral injuries not repaired, surgical misuse of the spermatic cord and not found and repaired in time; inflammatory diseases of the reproductive system such as epididymitis, epididymal tuberculosis, prostatitis, seminal vesiculitis, etc. can cause obstruction of the vas deferens; benign tumors of the seminal vesicles such as seminal cysts, etc.