Strictly speaking, surgery is not recommended for advanced lung cancer, and drug therapy is usually the main treatment, such as chemotherapy and radiotherapy for small cell lung cancer. For non-small cell lung cancer, especially adenocarcinoma or squamous carcinoma, genetic testing can be performed to find the appropriate targeted drug, which is also known as precision medicine, and molecular targeted therapy is preferred. Chemotherapy can also be preferred if there is no sensitive mutation and if the body type allows. In addition, immunotherapy targeting PD-1 and PD-L1 is emerging at home and abroad, and immunotherapy has just won the Nobel Prize in medicine as an emerging treatment, which has been rapidly promoted in China and is very promising in the treatment of lung cancer in the future. In conclusion, advanced lung cancer is mainly treated by conservative treatment and drug therapy, and in principle, surgery is not considered, unless the patient has oligometastasis, that is, the metastasis site is less and more limited, then surgery can be combined to achieve good clinical results.