The most effective way to treat and prevent septic thrombosis is to treat and prevent it based on the pathogenesis of sepsis, but unfortunately the pathogenesis of septic thrombosis is still not completely elucidated, in this case, prevention work should be done in all aspects of clinical practice in response to the pathogenesis, and efforts to reduce the risk factors that induce infection have an important role in the treatment and prevention of septic thrombosis. Early active enteral nutrition, strengthening metabolic and immune conditioning, and enhancing multi-organ function protection and support are important means to prevent and treat septic thrombosis. Performing early gastrointestinal feeding can effectively maintain its intestinal mucosal barrier function, provide sufficient protein and calories, promote the body’s positive nitrogen balance, reduce hypermetabolic reactions, improve the body’s immunity, and prevent and reduce the occurrence of systemic infections. Monitoring urine volume to ensure renal perfusion, appropriate alkalinization of urine, diuresis, etc. protect renal function, and perform hemofiltration and renal replacement therapy as early as possible for some patients with extremely high blood creatinine and urea nitrogen and clear indications for dialysis to stop the development of MOF at an early stage.