Adrenal glucocorticoids, commonly referred to as hormones, are one of the most commonly used drugs in clinical practice. Because of their powerful effects and easy availability, they are widely used in various regions. Some people even regard it as a “magic elixir” and try it no matter what diseases they have, and there are also many charlatans who mix hormones in the so-called “ancestral secret recipes” to cheat. There is no denying that the therapeutic value of hormones for some diseases is irreplaceable. However, the long-term application of large doses of hormones may have a variety of adverse effects on the human body, such as hyperglycemia, hyperlipidemia, osteoporosis, electrolyte disorders, hypoproteinemia and glaucoma, etc. It may affect the growth and development of children and may lead to poor wound healing. For a long time, many people are afraid of hormones and regard them as “demons”. In fact, hormones are only a tool for treating diseases. Making full use of hormones can benefit patients, while abusing or misusing them will do endless harm. Therefore, how to use hormones well is an art. In order to make the application of hormones more standardized and reduce adverse reactions, rheumatologists, through long-term clinical observation and practice, have put forward the “Recommendations for Systemic Application of Glucocorticoid Therapy”, which mainly contains the following contents. Strictly grasp the indications for hormones. Hormone is not a panacea, and it is necessary to master the indications strictly. As patients’ medical knowledge is insufficient, their understanding of drugs is often different from that of doctors, and if they cannot actively cooperate, the rate of non-standard treatment increases significantly. Therefore, patients should fully communicate with their doctors and follow medical advice. It is advisable to establish a “treatment card”, indicating the date of starting hormone therapy, the starting dose, as well as the method of dose reduction and maintenance. The correct use of hormones is the key to safe use. How to control the dose and duration of hormone therapy is the core issue. The application of hormones must follow the principle of individualization, and the selection of hormone dosage form, dose, route of administration and course of treatment should be different according to the different diseases and individual differences of patients, and should not be generalized. The time to take the medication should be as early as possible before 8:00 a.m. to coincide with the peak of physiological secretion. As far as possible, choose small doses, short courses of treatment, and short- and medium-acting dosage forms to reduce side effects, if the condition permits. Pay attention to the evaluation and prevention of adverse hormone reactions. The possible adverse reactions should be fully considered and prevented before hormone therapy. Blood pressure, blood glucose, blood lipids and bone density should be closely observed during the course of medication, and early intervention measures such as calcium and vitamin D supplementation should be taken. For patients with existing glaucoma, hormone therapy should be avoided as much as possible.