There is no scientific basis for the statement that “rabies vaccine is wasted when you drink alcohol”. In general, drinking alcohol, especially in small amounts, does not affect the time to produce antibodies or the number of antibodies produced, so the vaccination is effective. However, drinking alcohol may induce or aggravate adverse reactions to rabies vaccination or mask adverse reactions to the vaccine. Also, heavy or prolonged use of alcohol can lead to other risks, such as damage to the stomach mucosa and liver. Therefore, alcohol should not be consumed during rabies vaccination or at all times. Some vaccinees may experience fever, rash, and adverse reactions such as skin swelling, bloating, and diarrhea after rabies vaccination, and the symptoms may be somewhat aggravated after drinking alcohol. Some vaccinees who do not have adverse reactions themselves may induce adverse reactions to the vaccine under the effect of alcohol, such as gastrointestinal reactions such as abdominal pain and diarrhea due to irritation of the gastric mucosa, and excessive intake of alcohol may also cause some damage to the liver. In addition, since adverse reactions after drinking alcohol can be similar to those of the vaccine, drinking alcohol after rabies vaccination may mask adverse reactions to the vaccine, which is not conducive to the doctor’s determination of the cause of the symptoms. The rabies fatality rate is essentially 100%, and rabies vaccination is a more effective way to reduce rabies infection. In addition to not recommending alcohol, it is also important to avoid the intake of spicy and stimulating, cold and greasy foods, such as strong tea, coffee and chili peppers, and to avoid strenuous exercise. Patients who have been bitten or scratched by animals should follow the principle of timely, adequate and full vaccination to ensure the effectiveness of vaccination. Those who develop allergy during vaccination need to visit the hospital for anti-allergy treatment in time.